Monday, April 27, 2015

Large Pragmatic Studies to Evaluate Patient-Centered Outcomes - Spring 2015 Cycle

Additional Information:
http://www.pcori.org/announcement/large-pragmatic-studies-evaluate-patient-centered-outcomes-spring-2015-cycle

Description:
Patient-Centered Outcomes Research Institute (PCORI) seeks to fund pragmatic clinical trials, large simple trials, or large-scale observational studies that compare two or more alternatives for addressing prevention, diagnosis, treatment, or management of a disease or symptom; improving healthcare system-level approaches to managing care; or eliminating health or healthcare disparities.
Proposed studies must address critical clinical choices faced by patients, their caregivers, clinicians, and/or delivery systems. They must involve broadly representative patient populations and be large enough to provide precise estimates of hypothesized effectiveness differences, and to support evaluation of potential differences in treatment effectiveness in patient subgroups.
For this solicitation, PCORI is requiring that relevant patient organizations, professional organizations, and/or payer or purchaser organizations be included as partners and active participants in the study. PCORI expects that most awards will be made for study designs that use randomization, either of individual participants or clusters, to avoid confounding bias. However, we recognize that exceptional opportunities may arise, by virtue of natural experiments and/or the existence of large registries, to address pragmatic questions using observational designs.
Please note that this funding program does not support applications to conduct cost-effectiveness analyses, systematic reviews (with or without meta-analyses), or development and/or evaluations of shared decision making or decision support tools.
This announcement is a collaborative effort of PCORI’s Clinical Effectiveness Research, Improving Healthcare Systems, and Addressing Disparities research programs. Thus, applications for pragmatic studies may fit within any of these three priority areas.


Monday, April 6, 2015

Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)

Additional Information:
http://www.grants.gov/web/grants/view-opportunity.html?oppId=275615

Description:
This Funding Opportunity Announcement (FOA) encourages R21 applications that propose to conduct secondary analyses of existing data sets relevant to diabetes and selected endocrine and metabolic diseases including thyroid, parathyroid and Cushings diseases and acromegaly; and genetic metabolic disease including cystic fibrosis, lysosomal storage diseases, and disorders of the urea cycle, amino acid metabolism and metal transport where the focus is on peripheral metabolism or organ function; obesity, liver diseases, alimentary GI tract diseases and nutrition; kidney, urologic, and hematologic diseases. The goal of this program is to facilitate research that explores innovative hypotheses through the use of existing data sets.

Thursday, April 2, 2015

Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18)

Additional Information:
http://grants.nih.gov/grants/guide/pa-files/PAR-15-157.html

Description:
The purpose of this Research Demonstration and Dissemination Projects (R18) Funding Opportunity Announcement (FOA) is to encourage research applications to test approaches to improve diabetes and obesity prevention and/or treatment in routine healthcare settings.  Research applications should be designed to test practical and potentially sustainable strategies to improve processes of care and health outcomes for individuals who are overweight or obese or at risk for becoming overweight or obese and/or at risk for or have type 1 or type 2 diabetes. The goal of the research is to obtain results that will improve routine healthcare practice and inform healthcare policy for the prevention or management of these conditions. - See more at: http://grants.nih.gov/grants/guide/pa-files/PAR-15-157.html#sthash.dhpabH9O.dpuf

Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34)

Additional Information:
http://grants.nih.gov/grants/guide/pa-files/PAR-15-158.html

Description:
The purpose of this Planning Grant (R34) Funding Opportunity Announcement (FOA) is to encourage research applications to develop and pilot test approaches to improve diabetes and obesity prevention and/or treatment in routine healthcare settings.  Research applications should be designed to pilot test practical and potentially sustainable strategies to improve processes of care and health outcomes for individuals who are overweight or obese or at risk for becoming overweight or obese and/or at risk for or have type 1 or type 2 diabetes. The goal is that, if the pilot study shows promise, the data from the R34 will be used to support a full scale trial focused on improving routine healthcare practice and informing healthcare policy for the prevention or management of diabetes and obesity.